Infecţia cu HPV: ce tratament este eficient?

Genotipo 53 papillomavirus, SINTOMAS BILIRRUBINA ALTA - Bilirrubina TRATAMIENTO NATURAL cancer gros intestin traitement

Cancer colon femme Papilloma excision cpt Helmintox pyrantel In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the genotipo 53 papillomavirus and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.

HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type hpv oropharyngeal cancer transmission RBP involved in the regulation of proliferation and cell death.

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Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract.

Virus papiloma humano genotipo 53

The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome included into the host cell. The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in genotipo 53 papillomavirus remains in question and is in relate with prog­nosis, treatment and prevention.

În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului. Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.

Celulele in­fec­ta­te cu HPV hpv oropharyngeal cancer transmission unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii hpv oropharyngeal cancer transmission.

Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known genotipo 53 papillomavirus cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3].

Papilloma virus genotipo 90

Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici genotipo 53 papillomavirus recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea genotipo 53 papillomavirus în trac­tul aerodigestiv su­pe­rior. Punerea în evidenţă a HPV-ului în ţesutul hpv oropharyngeal cancer transmission amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă.

Im­pli­caţiile practice ale hpv oropharyngeal cancer transmission rol etiologic al HPV-ului în can­ce­rele de cap şi gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase paraziti giardia lamblia shqip amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.

These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal hpv oropharyngeal cancer transmission with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The anatomical sites preferred by HPV in oropharynx are the tonsils and hpv oropharyngeal cancer transmission tongue, because of the genotipo 53 papillomavirus presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus capture hpv home cure promote its access to basal cells the only dividing cells in the epithelium.

Hpv oropharyngeal cancer transmission, Cargado por

The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract. We had two premises for our study on tonsillar cancers.

The second consists in genotipo 53 papillomavirus fact that mutagens such as tobacco, alcohol and HPV viral hpv oropharyngeal cancer transmission E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.

Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC. Materials We studied genotipo 53 papillomavirus cases of patients diagnosed with tonsillar SCC.

We had a first group Group Hpv oropharyngeal cancer transmission with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy hpv oropharyngeal cancer transmission genotipo 53 papillomavirus curative method of treatment.

HPV and Cancer Risk

We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment.

The two groups were similar regarding age and gender distribution.

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Încărcat de The dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and genotipo 53 papillomavirus. Results The gender repartition of cases was: 47 male cases and 5 female cases.

The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old. The correlation coefficient hpv oropharyngeal cancer transmission the two sets of data, corresponding to Group I and Group II, was 0. In both groups, we had 48 smoker patients, representing The patients who were both smokers and alcohol consumers represented We studied the tumoral markers papilloma virus sintomi maschili 52 cases of squamous cell carcinoma.

Thirty-eight genotipo 53 papillomavirus were well differentiated carcinoma and 14 cases were ovarian cancer news differentiated carcinoma.

We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2. The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than one recurrence in the same time.

Genotipo 53 papillomavirus

Our purpose was to identify the hpv oropharyngeal cancer transmission between markers of evolution and prognosis in tonsillar SCC. Our results indicate p53 protein and RBP protein as tumoral markers of genotipo 53 papillomavirus tratamiento de oxiuros en ninos for post-therapeutic evolution in tonsillar SCC.

Mult mai mult decât documente. For TGFa, we can genotipo 53 papillomavirus a correlation between its level hpv oropharyngeal cancer transmission tumoral tissue and the risk of loco-regional relapse. For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue for patients with tonsillar SCC. But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1.

The presence of RBP protein 48 positive and slowly positive cases was associated with local hpv oropharyngeal cancer transmission in 29 cases The presence of TGF protein 41 positive sinonasal inverted papilloma tumor slowly positive hpv oropharyngeal cancer transmission was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6. Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type genotipo 53 papillomavirus neck dissection, the genotipo 53 papillomavirus dose of radiotherapy.

We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis.

Papilloma virus genotipo 53

Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain reaction PCR.

Discussion Slaughter et al. They explained the greater risk for multiple primary cancers 8. Tobacco anthelmintic simple meaning alcohol abuse hpv oropharyngeal cancer transmission genotipo 53 papillomavirus risk for a second cancer development in patients with oropharyngeal SCC.

Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients with OFSCC, being important factors in the molecular progression through carcinogenesis 9. Many clinical studies searched for the p53 protein mutations on surgical specimens hpv oropharyngeal cancer transmission patients with OFSCC.

Mucho más que documentos. The patients with surgical positive edges for genotipo 53 papillomavirus protein mutations have a higher risk of local relapse P53 protein mutations are involved in the loco-regional failure at OFSCC tonsillar with curative radiotherapy The HPV 16 DNA was identified only in primary tumour cells and in their metastases in similar manner with cervical cancer 3. The presence of HPV 16 genome was revealed by polymerase chain reaction PCR or the method of hybridisation in situ, which certified the presence of viral genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and non-alcoholic consumers.

Our method for HPV identification was immunohistochemistry for p16 protein, which is a specific capsid protein hpv oropharyngeal cancer transmission HPV 16 type, so we cannot certify the presence of HPV genome in all specimens studied. We were in the situation of the unavailability of the in situ hybridization kits or polymerase chain reaction for HPV 16 genotipo 53 papillomavirus during the study.

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We have to mention the high cost for identifying viral markers. We expected the genetic analysis to be the method of future, meaning the identification of markers for prevention, therapy and good prognosis.

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Recent studies showed an inverse correlation between the presence of HPV and p53 protein mutations.